Following an establishing shot of the New York City skyline, an elevator in a busy office building opens and happy-go-lucky Sky Ames (Lew Ayres) steps out. In a joyful mood, singing to himself, he takes out a ring, puts it on third finger of his left hand and goes to the door marked "Eaton, Eiton, Piper & Holland Advertising Agency". Inside, Miss Wilson (Sara Haden), secretary to his best friend, Jeff Holland (Robert Taylor) tells him that Jeff is in a meeting. Showing her the ring, Sky explains that during the first vacation he took without Jeff, he met "the most wonderful girl in the world".
In Jeff's office, Mr. McIntyre (George Barbier) the ill-tempered health-tonic tycoon is complaining to Jeff and his elderly deaf partner, Mr. Piper (Richard Carle) that after spending a million dollars per year on advertising, he has the right to anticipate better results and, "if you can't put over this health tonic, I'll take the account to another advertising firm that can". He leaves, telling Jeff that he expects to see him at the 3 o'clock board meeting, angrily adding "sharp". Spotting Sky, Jeff asks about his trip to Nassau and Sky invites him for lunch at the Colony, a luxury restaurant renowned for its elite patronage.
Betty Applewhite and Caleb prepare for their departure from Wisteria Lane in the middle of the night. In the present, as Betty and Caleb leave their house, the police surround them and they are placed into police cars as the entire neighborhood watches.
Meanwhile, Bree begins her stay at the psychiatric hospital where she meets up with Susan's new friend, Orson Hodge, who is visiting a sick friend. Bree is embarrassed and says she is not like the other people there which Orson accepts graciously. Orson then proceeds to talk to his friend who stares out a window. During a therapy session, the doctor finds Bree troubled but has problems to relate to her since Bree will not explain her reasons for admitting herself. Bree receives a phone call from Betty who tells her that she believes Matthew, not Caleb, killed Melanie, and that Bree's daughter, Danielle, is in danger. When Bree attempts to leave she is put into restraints and is forced to remain in bed. During another session, she throws the contents of a miniature Zen sand garden at the doctor and makes a run for the door. Bree is seen by Orson who looks on without intervening.